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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:9665
Term: triadimefon
Definition: A racemate comprising equal amounts of (R)- and (S)-triadimefon. A fungicide used to control powdery mildew, rusts and other infections in crops.
Chemical ID: MESH:C032910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3multiple interactionsISONr1h3 (Mus musculus)6480464CTDNR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of BIRC5 mRNA]; NR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of CYP2B10 mRNA]; NR1H3 gene mutant form inhibits the reaction [triadimefon results in increased expression of CYP3A11 mRNA]; NR1H3 gene mutant form promotes the reaction [triadimefon results in increased expression of GSTM3 mRNA]PMID:25949234
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