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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3increases expressionISONr1h3 (Mus musculus)6480464CTDGenistein results in increased expression of NR1H3 mRNAPMID:32186404
Nr1h3multiple interactionsISONR1H3 (Homo sapiens)6480464CTDGenistein promotes the reaction [NR1H3 protein binds to SULT2A1 promoter]; NR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 mRNA]; NR1H3 protein affects the reaction [Genistein results in increased expression of SULT2A1 protein]PMID:23352501
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