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GENE - TERM ANNOTATION REPORT

RGD ID: 61898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: DOID:13413
Term: hepatic encephalopathy
Definition: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Definition Source(s): MESH:D006501, https://docs.google.com/spreadsheets/d/1k1O_aBn3qpABVB315sNZtqviqqNFC6iY7xHWiTVOuhM/edit#gid=0, https://en.wikipedia.org/wiki/Hepatic_encephalopathy
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:73575111554173CTDCTD Direct Evidence: marker/mechanism

PMID:9048767, PMID:10206825, PMID:10564534
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.