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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: CHEBI:7930
Term: Pargyline
Definition: An aromatic amine that has formula C11H13N.
Chemical ID: MESH:D010293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:621916480464CTDPargyline results in decreased activity of MAOA protein

PMID:20716577
multiple interactionsISORGD:621916480464CTD[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]], [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

PMID:23499958
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.