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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4' 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:621916480464CTDLuteolin results in decreased activity of MAOA protein

PMID:23009399
decreases activityISORGD:7357516480464CTDLuteolin results in decreased activity of MAOA protein

PMID:23009399
multiple interactionsISORGD:621916480464CTDLuteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde], Luteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde], Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]

PMID:23009399
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.