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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k2increases phosphorylationISOMAP2K2 (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of MAP2K2 proteinPMID:19038232
Map2k2multiple interactionsISOMAP2K2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K2 proteinPMID:20615082
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