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GENE - TERM ANNOTATION REPORT

RGD ID: 61883
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ghrh
Name: growth hormone releasing hormone
Acc ID: GO:0007189
Term: adenylate cyclase-activating G protein-coupled receptor signaling pathway
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Definition Source(s): GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ghrh IDA 628502RGD  
Ghrhacts_upstream_of_or_withinISOGhrh (Mus musculus)1624291RGDMGI:95710 PMID:10537133 PMID:1334535 PMID:8391647 PMID:8395283

PMID:10537133 PMID:1334535 PMID:8391647 PMID:8395283
Ghrhacts_upstream_of_or_withinISOGHRH (Homo sapiens)1624291RGD PMID:3008329

PMID:3008329
Ghrhinvolved_inISOGhrh (Mus musculus)1624291RGD PMID:11773624

PMID:11773624
Ghrhinvolved_inISOGHRH (Homo sapiens)1624291RGD PMID:1333056 PMID:7680413

PMID:1333056 PMID:7680413
Ghrhinvolved_inIBAMGI:105094 or MGI:95709 or MGI:98933 or PANTHER:PTN000130195 or Adcyap1 (Rattus norvegicus) or Ghrh (Rattus norvegicus) or Vip (Rattus norvegicus) or UniProtKB:P01282 or UniProtKB:P01286 or UniProtKB:P18509 or UniProtKB:P41535 or UniProtKB:P48143 or UniProtKB:P81401 or UniProtKB:Q29W191600115GO_CentralGO_REF:0000033

GO_REF:0000033
Ghrhinvolved_inIEAARBA:ARBA000290261600115UniProtGO_REF:0000117

GO_REF:0000117
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