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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpc1
Name: glypican 1
Acc ID: CHEBI:27363
Term: zinc atom
Definition: A zinc group element atom that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:621456480464CTD[APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form, Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]], Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form]

PMID:12732622, PMID:15677459
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.