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GENE - TERM ANNOTATION REPORT

RGD ID: 61824
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj16
Name: potassium inwardly-rectifying channel, subfamily J, member 16
Acc ID: GO:0005242
Term: inward rectifier potassium channel activity
Definition: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
Definition Source(s): GOC:cb, GOC:mah, PMID:14977398
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj16enablesIBAFB:FBgn0039081 or FB:FBgn0265042 or MGI:104781 or MGI:107501 or MGI:1194504 or PANTHER:PTN000205946 or Kcnj1 (Rattus norvegicus) or Kcnj8 (Rattus norvegicus) or Kcnj15 (Rattus norvegicus) or Kcnj14 (Rattus norvegicus) or Kcnj11 (Rattus norvegicus) or UniProtKB:B7U540 or UniProtKB:E7FD27 or UniProtKB:F1NHE9 or UniProtKB:P63252 or UniProtKB:Q14500 or UniProtKB:Q15842 or WB:WBGene00002149 or ZFIN:ZDB-GENE-031118-55 or ZFIN:ZDB-GENE-091118-79 or ZFIN:ZDB-GENE-100922-48 or ZFIN:ZDB-GENE-120319-1 or ZFIN:ZDB-GENE-131126-141600115GO_CentralGO_REF:0000033

GO_REF:0000033
Kcnj16enablesIEAInterPro:IPR008061 or InterPro:IPR0164491600115InterProGO_REF:0000002

GO_REF:0000002
Kcnj16enablesIEAPANTHER:PTHR11767:SF241600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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