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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsk
Name: cathepsin K
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctskaffects expressionISOCtsk (Mus musculus)6480464CTDGenistein affects the expression of CTSK mRNAPMID:17166402
Ctskdecreases expressionISOCtsk (Mus musculus)6480464CTDGenistein results in decreased expression of CTSK mRNAPMID:17295206
Ctskmultiple interactionsISOCtsk (Mus musculus)6480464CTD[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA; Genistein promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Zinc Sulfate] results in decreased expression of CTSK mRNA]; Zinc Sulfate promotes the reaction [[CSF1 protein co-treated with TNFSF11 protein co-treated with Genistein] results in decreased expression of CTSK mRNA]; Zinc Sulfate promotes the reaction [Genistein results in decreased expression of CTSK mRNA]PMID:17295206
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