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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61808
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faah
Name: fatty acid amide hydrolase
Acc ID: CHEBI:28787
Term: nitroglycerin
Definition: A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Chemical ID: MESH:D005996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faahincreases activityEXP 6480464CTDNitroglycerin results in increased activity of FAAH proteinPMID:19515121
Faahmultiple interactionsEXP 6480464CTDNitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]PMID:19515121
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