GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Crhr1 | multiple interactions | EXP | | 6480464 | CTD | [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone | PMID:24398105 | Crhr1 | increases response to substance | ISO | Crhr1 (Mus musculus) | 6480464 | CTD | CRHR1 gene mutant form results in increased susceptibility to Naloxone | PMID:28434951 | Crhr1 | multiple interactions | ISO | Crhr1 (Mus musculus) | 6480464 | CTD | CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] | PMID:25582704 | |
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