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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
Acc ID: CHEBI:7459
Term: naloxone
Definition: A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
Chemical ID: MESH:D009270
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhr1multiple interactionsEXP 6480464CTD[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to NaloxonePMID:24398105
Crhr1increases response to substanceISOCrhr1 (Mus musculus)6480464CTDCRHR1 gene mutant form results in increased susceptibility to NaloxonePMID:28434951
Crhr1multiple interactionsISOCrhr1 (Mus musculus)6480464CTDCRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]PMID:25582704
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