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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase family 1 member A1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1multiple interactionsEXP 6480464CTDCurcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]PMID:20015472
Ugt1a1increases expressionISOUgt1a1 (Mus musculus)6480464CTDCurcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 proteinPMID:26991801 PMID:29228771
Ugt1a1increases expressionISOUGT1A1 (Homo sapiens)6480464CTDCurcumin results in increased expression of UGT1A1 mRNAPMID:16819192
Ugt1a1increases glucuronidationISOUGT1A1 (Homo sapiens)6480464CTDUGT1A1 protein results in increased glucuronidation of CurcuminPMID:14557274
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