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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tpm1
Name: tropomyosin 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpm1decreases expressionISOTpm1 (Mus musculus)6480464CTDDexamethasone results in decreased expression of TPM1 mRNA; Dexamethasone results in decreased expression of TPM1 proteinPMID:22733784 PMID:33567340
Tpm1decreases expressionISOTPM1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of TPM1 mRNAPMID:25047013
Tpm1multiple interactionsISOTpm1 (Mus musculus)6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TPM1 mRNAPMID:16054899
Tpm1multiple interactionsISOTPM1 (Homo sapiens)6480464CTD[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TPM1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of TPM1 mRNAPMID:16997883 PMID:28628672
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