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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:15843
Term: arachidonic acid
Definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
Chemical ID: MESH:D016718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases abundanceISOTnf (Mus musculus)6480464CTDTNF protein results in increased abundance of Arachidonic AcidPMID:10588948
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDTNF protein results in increased secretion of Arachidonic AcidPMID:1515551
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDButylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]; TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]PMID:10588948
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDArachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid]PMID:1515551 PMID:15684433
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