GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases expression | EXP | | 6480464 | CTD | troglitazone results in decreased expression of TNF mRNA; troglitazone results in decreased expression of TNF protein | PMID:11328671 PMID:9502777 | Tnf | multiple interactions | EXP | | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [[Troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; [Troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [Troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] | PMID:21153920 | Tnf | decreases activity | ISO | TNF (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased activity of TNF protein | PMID:16483873 | Tnf | decreases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | troglitazone results in decreased expression of TNF mRNA | PMID:10807946 | Tnf | decreases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased expression of TNF mRNA | PMID:16483873 PMID:19631733 | Tnf | decreases response to substance | ISO | Tnf (Mus musculus) | 6480464 | CTD | troglitazone results in decreased susceptibility to TNF protein | PMID:11911853 | Tnf | decreases response to substance | ISO | TNF (Homo sapiens) | 6480464 | CTD | troglitazone results in decreased susceptibility to TNF protein | PMID:7956951 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | troglitazone results in increased expression of TNF mRNA | PMID:19631733 | Tnf | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | troglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; troglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] | PMID:10807946 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | Genistein promotes the reaction [troglitazone inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; PPARA protein affects the reaction [troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; T 0070907 inhibits the reaction [troglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [troglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; troglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased expression of CEBPA mRNA]]; troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]; troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]]; troglitazone inhibits the reaction [TNF protein results in decreased expression of PPARG mRNA]; troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; troglitazone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; troglitazone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; troglitazone inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; troglitazone promotes the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of CDKN1A mRNA] | PMID:10441511 PMID:14534369 PMID:15531761 PMID:16483873 PMID:22124178 PMID:7956951 | | ||||||||||||||||||||||
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