A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID:
MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Dexamethasone inhibits the reaction [Ethylene dibromide increases expression of Tnf mRNA in liver], Dexamethasone inhibits the reaction [Lead nitrate increases expression of Tnf mRNA in liver]
Dexamethasone inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [nitrofen results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [nitrofen results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Oleic Acid results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [sephadex results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone metabolite]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]
[bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of TNF mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA; butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Glycosides metabolite results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased activity of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [Ovalbumin results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Ovalbumin results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Silicon Dioxide results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Ceramides]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of and results in increased localization of RELA protein]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CXCL15 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of MADCAM1 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; Dexamethasone inhibits the reaction [Zymosan results in increased secretion of TNF protein]; Dexamethasone promotes the reaction [Ovalbumin results in increased expression of TNF mRNA]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Lipopolysaccharides inhibits the reaction [Dexamethasone results in increased expression of TNF]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of TNF protein]; TNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; TNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG mRNA]; TNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORA mRNA]; TNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORC mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL10 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL12 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL7 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL16 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL5 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of ICAM1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP1A mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP9 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of VCAM1 mRNA]
4,4'-hexafluorisopropylidene diphenol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in decreased expression of TNF mRNA]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in decreased expression of TNF mRNA; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of TNF protein]; Dexamethasone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [IL1B protein results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [IL1B protein results in increased expression of TNF]; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Dexamethasone inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Dexamethasone inhibits the reaction [TNF protein results in decreased expression of BIRC2 protein]; Dexamethasone inhibits the reaction [TNF protein results in decreased expression of BIRC3 protein]; Dexamethasone inhibits the reaction [TNF protein results in decreased expression of XIAP protein]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dexamethasone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CASP1 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of HMOX1 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of CSF2 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; Dexamethasone inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; Dexamethasone inhibits the reaction [Zymosan results in increased expression of TNF protein]; Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]]; NR3C1 protein promotes the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; PPP2CA protein promotes the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Theophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]; Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]
