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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:34714
Term: dimethoate
Definition: A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Chemical ID: MESH:D004117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDDimethoate results in increased expression of TNF mRNAPMID:23891859 PMID:23943137
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDEstradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]]PMID:23943137
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