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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:30512
Term: silver atom
Definition: A copper group element atom that has formula Ag.
Chemical ID: MESH:D012834
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDSilver analog results in increased expression of TNF mRNA; Silver results in increased expression of TNF proteinPMID:20713472 PMID:23086748 PMID:27417253
Tnfdecreases secretionISOTNF (Homo sapiens)6480464CTDSilver results in decreased secretion of TNF proteinPMID:17996693
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDSilver results in increased expression of TNF mRNA; Silver results in increased expression of TNF proteinPMID:19969064 PMID:22820426
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDSilver analog results in increased expression of TNF mRNA; Silver results in increased expression of TNF mRNAPMID:23086748 PMID:26968431
Tnfincreases secretionISOTnf (Mus musculus)6480464CTDSilver results in increased secretion of TNF proteinPMID:19969064
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDSilver results in increased secretion of TNF proteinPMID:20064793
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDSilver promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]PMID:26968431
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