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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:28315
Term: alloxanthine
Definition: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Chemical ID: MESH:D010117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDOxypurinol results in increased expression of TNF mRNAPMID:26641773
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDOxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]PMID:28949055
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