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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDMustard Gas results in increased expression of TNF proteinPMID:20659490 PMID:33002157 PMID:34390737
Tnfincreases secretionEXP 6480464CTDMustard Gas results in increased secretion of TNF proteinPMID:27605419
Tnfmultiple interactionsEXP 6480464CTDAEOL 10150 inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Mustard Gas results in increased expression of and results in increased secretion of TNF proteinPMID:27605419 PMID:29129815
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDMustard Gas results in increased expression of TNF mRNA; Mustard Gas results in increased expression of TNF proteinPMID:16001271 PMID:19778212 PMID:21939433 PMID:25275893 PMID:29935281
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDMustard Gas results in increased expression of TNF mRNA; Mustard Gas results in increased expression of TNF proteinPMID:10025362 PMID:11428645 PMID:15251176 PMID:15868479 PMID:16173061 PMID:17266442 PMID:17524151 PMID:20143454 PMID:23851002 PMID:25102026
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDMustard Gas results in increased secretion of TNF proteinPMID:22036725 PMID:23851002 PMID:31048000
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDIodine inhibits the reaction [Mustard Gas results in increased expression of TNF protein]PMID:16001271
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDAcetaminophen promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; Celecoxib inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of TNF protein]; Indomethacin affects the reaction [Mustard Gas results in increased secretion of TNF protein]; MAPK14 mutant form inhibits the reaction [Mustard Gas results in increased expression of TNF protein]; MAPK14 protein affects the reaction [Mustard Gas results in increased expression of TNF mRNA]; MAPKAPK2 protein affects the reaction [Mustard Gas results in increased expression of TNF mRNA]; MAPKAPK2 protein affects the reaction [Mustard Gas results in increased secretion of TNF protein]; Mustard Gas results in increased expression of and results in increased secretion of TNF protein; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of TNF protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased secretion of TNF protein]; TNF protein affects the reaction [Mustard Gas affects the expression of CXCL2 mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of CXCL8 mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of FASLG mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of FGF7 mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of GDF1 mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of IL13 mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of IL7R mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of TNFRSF1A mRNA]; TNF protein affects the reaction [Mustard Gas affects the expression of TNFRSF1B mRNA]; TNF protein promotes the reaction [Mustard Gas results in increased expression of CXCL8 protein]; TNF protein promotes the reaction [Mustard Gas results in increased expression of IL6 protein]PMID:15251176 PMID:15868479 PMID:16173061 PMID:17524151 PMID:20143454 PMID:22036725 PMID:23851002 PMID:31048000
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