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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:17313
Term: 7,8-dihydroxycoumarin
Definition: A hydroxycoumarin that has formula C9H6O4.
Chemical ID: MESH:C039952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDdaphnetin inhibits the reaction [Benzene results in increased expression of TNF protein]PMID:33749080
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDdaphnetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]PMID:37209277
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]PMID:37209277
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