GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | affects expression | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | Cyclosporine affects the expression of TLR4 mRNA | PMID:34681664 | Tlr4 | increases expression | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | Cyclosporine results in increased expression of TLR4 mRNA; Cyclosporine results in increased expression of TLR4 protein | PMID:27585667 | Tlr4 | multiple interactions | ISO | TLR4 (Homo sapiens) | 6480464 | CTD | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine] results in increased expression of TLR4 mRNA | PMID:33819548 | Tlr4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of TLR4 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of TLR4 protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of ATF3 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of COL1A2 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CXCL10 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of DDIT3 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of ERN1 protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of FN1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of HAVCR1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of ICAM1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of JUN protein modified form]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of LCN2 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of NFKBIA protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of SERPINE1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of STAT3 protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of TNFRSF12A mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of TNFRSF12A protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of VCAM1 mRNA] | PMID:27585667 | | ||||||||||||||||||||||
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