GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Th | affects expression | EXP | | 6480464 | CTD | Valproic Acid affects the expression of TH protein | PMID:19460635 | Th | decreases expression | EXP | | 6480464 | CTD | Valproic Acid results in decreased expression of TH mRNA; Valproic Acid results in decreased expression of TH protein | PMID:18976638 PMID:33150595 | Th | increases expression | EXP | | 6480464 | CTD | Valproic Acid results in increased expression of TH mRNA; Valproic Acid results in increased expression of TH protein | PMID:18976638 | Th | increases methylation | EXP | | 6480464 | CTD | Valproic Acid results in increased methylation of TH promoter | PMID:33150595 | Th | multiple interactions | EXP | | 6480464 | CTD | CREB1 protein affects the reaction [Valproic Acid results in increased expression of TH mRNA]; Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of TH protein] | PMID:18976638 PMID:19149911 | Th | affects expression | ISO | Th (Mus musculus) | 6480464 | CTD | Valproic Acid affects the expression of TH mRNA | PMID:17963808 | Th | affects expression | ISO | TH (Homo sapiens) | 6480464 | CTD | Valproic Acid affects the expression of TH mRNA | PMID:25979313 | Th | multiple interactions | ISO | Th (Mus musculus) | 6480464 | CTD | Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH mRNA]; Valproic Acid inhibits the reaction [manganese chloride results in decreased expression of TH protein] | PMID:29778792 | | ||||||||||||||||||||||
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