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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3828
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf1a
Name: HNF1 homeobox A
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf1adecreases expressionISOHNF1A (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of HNF1A mRNA; perfluorooctanoic acid results in decreased expression of HNF1A proteinPMID:22609092 PMID:25868421
Hnf1amultiple interactionsISOHNF1A (Homo sapiens)6480464CTD[perfluorooctanoic acid results in decreased activity of HNF4A protein] which results in decreased expression of HNF1A mRNAPMID:22609092
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