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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3786
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc8
Name: ATP binding cassette subfamily C member 8
Acc ID: CHEBI:27999
Term: tolbutamide
Definition: An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Chemical ID: MESH:D014044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc8multiple interactionsISOABCC8 (Homo sapiens)6480464CTD[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]PMID:18025464 PMID:22209866 PMID:9568693
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