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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3783
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sts
Name: steroid sulfatase
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stsincreases expressionISOSTS (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of STS mRNAPMID:31217279
Stsmultiple interactionsISOSTS (Homo sapiens)6480464CTDprolinedithiocarbamate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STS protein]; RELA protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of STS protein]; STS protein affects the reaction [Estrogens, Conjugated (USP) promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TFF1 mRNA]]; STS protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Estradiol]; Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of STS proteinPMID:26220752 PMID:31217279
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