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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDnickel sulfate results in decreased expression of STAR mRNA, nickel sulfate results in decreased expression of STAR protein

PMID:29567110
multiple interactionsEXP 6480464CTD[CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA, [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR protein, Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA], Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR protein], pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA], pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR protein], SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA], SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR protein], TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA], TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR protein], U 0126 inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA], U 0126 inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]

PMID:29567110
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.