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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of STAR mRNA, Estradiol results in decreased expression of STAR protein

PMID:20144698, PMID:22142692, PMID:22771390, PMID:23209616
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Estradiol results in decreased expression of STAR mRNA]

PMID:23209616
decreases expressionISORGD:113506480464CTDEstradiol results in decreased expression of STAR mRNA

PMID:14630719
increases expressionISORGD:113506480464CTDEstradiol results in increased expression of STAR mRNA

PMID:30196065
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.