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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3764
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sstr4
Name: somatostatin receptor 4
Acc ID: CHEBI:53076
Term: 4-(ethoxymethylene)-2-phenyloxazol-5-one
Definition: A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity.
Chemical ID: MESH:D010081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7355516480464CTDSSTR4 results in decreased susceptibility to Oxazolone

PMID:19622729
multiple interactionsISORGD:7355516480464CTDSSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of IL1B protein]

SSTR4 gene mutant form promotes the reaction [Oxazolone results in increased expression of TNF protein]

PMID:19622729
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.