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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTD3, 4, 5, 3', 4'-pentachlorobiphenyl results in decreased expression of SRD5A1 mRNA

PMID:20959002
multiple interactionsEXP 6480464CTD[3, 4, 5, 3', 4'-pentachlorobiphenyl co-treated with 2, 2', 3', 4, 4', 5-hexachlorobiphenyl co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein, [3, 4, 5, 3', 4'-pentachlorobiphenyl co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNA

PMID:16984957, PMID:19464308
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.