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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpina3nincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of SERPINA3N mRNAPMID:21839799
Serpina3nincreases expressionISOSERPINA3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of SERPINA3 mRNAPMID:22316170 PMID:26238291
Serpina3nincreases expressionISOSerpina3n (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SERPINA3N mRNAPMID:20713471 PMID:21569818 PMID:22228805
Serpina3nincreases methylationISOSERPINA3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of SERPINA3 5' UTRPMID:27901495
Serpina3nmultiple interactionsISOSERPINA3 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SERPINA3 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of SERPINA3 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SERPINA3 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SERPINA3 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SERPINA3 mRNAPMID:17690111
Serpina3nmultiple interactionsISOSerpina3n (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to SERPINA3N promoter]PMID:19654925
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