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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SP1 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Sp1increases expressionEXP 6480464CTDbisphenol A results in increased expression of SP1 mRNAPMID:25181051 PMID:33296240
Sp1affects methylationISOSp1 (Mus musculus)6480464CTDbisphenol A affects the methylation of SP1 promoterPMID:27334623
Sp1decreases expressionISOSp1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SP1 mRNAPMID:33221593 PMID:37894381
Sp1increases expressionISOSP1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of SP1 mRNA; bisphenol A results in increased expression of SP1 proteinPMID:29783106 PMID:30206973
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTD[Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNAPMID:29783106
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