GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | increases expression | ISO | SP1 (Homo sapiens) | 6480464 | CTD | Copper deficiency results in increased expression of SP1 mRNA; Copper deficiency results in increased expression of SP1 protein | PMID:22172574 PMID:24132751 | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein]; [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; Copper deficiency promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]; Copper inhibits the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] | PMID:12633744 PMID:18483225 PMID:22172574 | | ||||||||||||||||||||||
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