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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:7596
Term: nitroprusside
Definition: An iron coordination entity that has formula C5FeN6O.
Chemical ID: MESH:D009599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases response to substanceISOSOD2 (Homo sapiens)6480464CTDSOD2 protein results in increased susceptibility to NitroprussidePMID:10511315
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]; [Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]PMID:20674559
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