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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases activityEXP 6480464CTDIndomethacin results in decreased activity of SOD2 proteinPMID:11523592
Sod2increases expressionEXP 6480464CTDIndomethacin results in increased expression of SOD2 mRNA; Indomethacin results in increased expression of SOD2 proteinPMID:22653900 PMID:36868495
Sod2multiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]; Indomethacin inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; rebamipide promotes the reaction [Indomethacin results in increased expression of SOD2 protein]PMID:11523592 PMID:16982041 PMID:21983654 PMID:22653900
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDIndomethacin affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]PMID:20304815
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDIndomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Indomethacin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]PMID:12031898
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