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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 mRNA]; Fulvestrant inhibits the reaction [sannoshashinto affects the activity of SOD2 protein]PMID:12816884 PMID:23615023
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Coumestrol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [daidzein results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [kaempferol results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [polydatin results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [resveratrol results in increased expression of SOD2 protein]PMID:21215799 PMID:23526725 PMID:24361291
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in decreased expression of and results in decreased activity of SOD2 protein]]PMID:20962025
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