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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of SOD1 proteinPMID:20935162
Sod1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SOD1 proteinPMID:17761372 PMID:18544905 PMID:20935162
Sod1decreases expressionISOSod1 (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of SOD1 mRNAPMID:19107877
Sod1increases expressionISOSod1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of SOD1 proteinPMID:17942915
Sod1multiple interactionsISOSod1 (Mus musculus)6480464CTDindoleacetic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of SOD1 mRNA]; MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of SOD1 protein]PMID:17942915 PMID:19107877
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