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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SOD1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD1 mRNA; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SOD1 mRNA]PMID:30835071 PMID:33127376 PMID:33171135 PMID:36757007
Sod1decreases expressionISOSod1 (Mus musculus)6480464CTDArsenic results in decreased expression of SOD1 proteinPMID:22552367
Sod1increases expressionISOSOD1 (Homo sapiens)6480464CTDArsenic results in increased expression of SOD1 mRNAPMID:11134558
Sod1multiple interactionsISOSOD1 (Homo sapiens)6480464CTD[[Industrial Waste results in increased abundance of Trace Elements] which results in increased abundance of Arsenic] which affects the expression of SOD1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SOD1 mRNAPMID:34083740 PMID:37325564
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