GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod1 | affects abundance | ISO | Sod1 (Mus musculus) | 6480464 | CTD | SOD1 protein affects the abundance of Glutathione | PMID:16377630 | Sod1 | affects activity | ISO | Sod1 (Mus musculus) | 6480464 | CTD | Glutathione deficiency affects the activity of SOD1 protein | PMID:15707499 | Sod1 | increases abundance | ISO | Sod1 (Mus musculus) | 6480464 | CTD | SOD1 gene mutant form results in increased abundance of Glutathione | PMID:27349771 | Sod1 | multiple interactions | ISO | Sod1 (Mus musculus) | 6480464 | CTD | [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein]; SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form]; Thioacetamide promotes the reaction [SOD1 gene mutant form results in increased abundance of Glutathione] | PMID:16636302 PMID:27349771 | Sod1 | multiple interactions | ISO | SOD1 (Homo sapiens) | 6480464 | CTD | [Glutathione results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Glutathione results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; Glutathione results in increased reduction of and results in decreased activity of SOD1 protein | PMID:16101137 PMID:22867017 PMID:31162603 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |