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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3717
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc8a1
Name: solute carrier family 8 member A1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc8a1decreases expressionEXP 6480464CTDOxygen deficiency results in decreased expression of SLC8A1 mRNAPMID:25937560
Slc8a1increases expressionEXP 6480464CTDOxygen deficiency results in increased expression of SLC8A1 mRNA; Oxygen deficiency results in increased expression of SLC8A1 proteinPMID:17394575 PMID:21293012
Slc8a1multiple interactionsEXP 6480464CTD[[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 mRNA; [Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of SLC8A1 protein; HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of SLC8A1 protein]; Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA]PMID:21293012 PMID:25937560
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