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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:32168
Term: sulpiride
Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Chemical ID: MESH:D013469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3multiple interactionsISOSlc6a3 (Mus musculus)6480464CTDSulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC6A3 protein]PMID:30922767
Slc6a3multiple interactionsISOSLC6A3 (Homo sapiens)6480464CTDSulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]; Sulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]PMID:20875051
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