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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a4
Name: solute carrier family 6 member 4
Acc ID: CHEBI:9123
Term: sertraline
Definition: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Chemical ID: MESH:D020280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a4decreases expressionEXP 6480464CTDSertraline results in decreased expression of SLC6A4 proteinPMID:12151556
Slc6a4increases expressionEXP 6480464CTDSertraline results in increased expression of SLC6A4 mRNAPMID:18650020
Slc6a4multiple interactionsEXP 6480464CTD[Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNA; [Sertraline results in decreased expression of SLC6A4 protein] which results in decreased metabolism of Selective Serotonin Reuptake Inhibitors; Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]PMID:12151556 PMID:18650020
Slc6a4affects bindingISOSLC6A4 (Homo sapiens)6480464CTDSertraline binds to SLC6A4 proteinPMID:33124469
Slc6a4affects response to substanceISOSLC6A4 (Homo sapiens)6480464CTDSLC6A4 protein affects the susceptibility to SertralinePMID:12955294
Slc6a4decreases expressionISOSlc6a4 (Mus musculus)6480464CTDSertraline results in decreased expression of SLC6A4 proteinPMID:18923402
Slc6a4increases expressionISOSlc6a4 (Mus musculus)6480464CTDSertraline results in increased expression of SLC6A4 mRNAPMID:34262461
Slc6a4increases response to substanceISOSLC6A4 (Homo sapiens)6480464CTDSLC6A4 promoter polymorphism results in increased susceptibility to SertralinePMID:12955294
Slc6a4multiple interactionsISOSlc6a4 (Mus musculus)6480464CTD[Cannabidiol co-treated with Sertraline] results in increased expression of SLC6A4 mRNAPMID:34262461
Slc6a4multiple interactionsISOSLC6A4 (Homo sapiens)6480464CTDSertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]PMID:17042913
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