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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:131461
Term: 3-bromopyruvic acid
Definition: A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug
Chemical ID: MESH:C017092
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a1decreases expressionISOSlc2a1 (Mus musculus)6480464CTDbromopyruvate results in decreased expression of SLC2A1 mRNA; bromopyruvate results in decreased expression of SLC2A1 proteinPMID:28433571
Slc2a1multiple interactionsISOSlc2a1 (Mus musculus)6480464CTD[bromopyruvate results in decreased expression of SLC2A1 protein] which results in decreased uptake of GlucosePMID:28433571
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