GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shh | multiple interactions | EXP | | 6480464 | CTD | cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased localization of GLI1 protein]]; cyclopamine inhibits the reaction [SHH protein inhibits the reaction [Lipopolysaccharides results in decreased expression of PTCH1 mRNA]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]; cyclopamine inhibits the reaction [SHH protein results in increased expression of PTCH1 protein]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH mRNA]; cyclopamine inhibits the reaction [Sodium Fluoride results in increased expression of SHH protein] | PMID:21110116 PMID:24388991 | Shh | decreases expression | ISO | Shh (Mus musculus) | 6480464 | CTD | cyclopamine results in decreased expression of SHH mRNA | PMID:20865013 | Shh | multiple interactions | ISO | SHH (Homo sapiens) | 6480464 | CTD | cyclopamine inhibits the reaction [SHH protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] | PMID:20434536 PMID:27481074 PMID:31642701 | Shh | multiple interactions | ISO | Shh (Mus musculus) | 6480464 | CTD | cyclopamine inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] | PMID:20395211 PMID:20434536 | | ||||||||||||||||||||||
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