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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3668
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
Acc ID: CHEBI:64211
Term: 8-Br-cAMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.
Chemical ID: MESH:D015124
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sgk1increases expressionISOSGK1 (Homo sapiens)6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNAPMID:21056929
Sgk1multiple interactionsISOSGK1 (Homo sapiens)6480464CTDEstradiol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]; Genistein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SGK1 mRNA]PMID:21056929
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