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GENE - TERM ANNOTATION REPORT

RGD ID: 3666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sftpc
Name: surfactant protein C
Acc ID: DOID:850
Term: lung disease
Definition: A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. (DO)
Definition Source(s): http://www.niehs.nih.gov/health/topics/conditions/lung-disease/index.cfm "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000066.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sftpc ISOSftpc (Mus musculus)4143420RGDLung Injury 
Sftpc ISOSFTPC (Homo sapiens)1624153RGDsurfactant metabolism dysfunction SMDP2,OMIM:610913;DNA:point mutation:intron:460+1G>A (human) 
Sftpc ISOSFTPC (Homo sapiens)4143451RGDAcute Lung Injury;mRNA:increased expression:pneumocyte 
Sftpc ISOSFTPC (Homo sapiens)4144117RGDDNA:missense mutation:exon:p.I73T (human) 
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