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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sftpa1
Name: surfactant protein A1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sftpa1decreases expressionISOSftpa1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of SFTPA1 proteinPMID:21724861
Sftpa1increases expressionISOSftpa1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of SFTPA1 mRNAPMID:21724861
Sftpa1increases expressionISOSFTPA1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of SFTPA1 mRNAPMID:23567252
Sftpa1multiple interactionsISOSftpa1 (Mus musculus)6480464CTDERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPA1 mRNA]; ERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPA1 protein]PMID:21724861
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