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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3651
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl12affects methylationISOCXCL12 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CXCL12 promoterPMID:27901495
Cxcl12decreases expressionISOCxcl12 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CXCL12 mRNAPMID:19770486 PMID:21569818
Cxcl12increases expressionISOCxcl12 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CXCL12; Benzo(a)pyrene results in increased expression of CXCL12 mRNAPMID:22228805 PMID:22342234 PMID:32553695
Cxcl12multiple interactionsISOCxcl12 (Mus musculus)6480464CTD[Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of CXCL12 mRNAPMID:32553695
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