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GENE - TERM ANNOTATION REPORT

RGD ID: 3637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn5a
Name: sodium voltage-gated channel alpha subunit 5
Acc ID: DOID:9005141
Term: Ventricular Tachycardia
Definition: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Definition Source(s): MESH:D017180
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn5a ISOSCN5A (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:18848812
Scn5a ISOSCN5A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Ventricular tachycardiaPMID:10807545 PMID:11901046 PMID:14967853 PMID:15176425 PMID:15851227 PMID:15992732 PMID:15996170 PMID:16379539 PMID:17210839 PMID:17210841 PMID:17587741 PMID:18378609 PMID:18426444 PMID:19027780 PMID:19412328 PMID:19632629 PMID:19841300 PMID:20129283 PMID:20636320 PMID:21109022 PMID:21167004 PMID:21705349 PMID:22378279 PMID:22581653 PMID:22677073 PMID:22685113 PMID:22840528 PMID:22995991 PMID:23299917 PMID:23414114 PMID:23465283 PMID:23571586 PMID:23861362 PMID:24033266 PMID:24055113 PMID:24317018 PMID:24667783 PMID:24721456 PMID:24721642 PMID:25554238 PMID:25637381 PMID:25741868 PMID:26159999 PMID:26406308 PMID:26467025 PMID:26743238 PMID:27153395 PMID:27287068 PMID:27381756 PMID:27435932 PMID:27711072 PMID:28087566 PMID:28341781 PMID:28492532 PMID:31043699 PMID:31918855
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